Scientists in US and Australia team up for ASF vaccine

The agency is working with US biotech firm MBF Therapeutics to evaluate their novel DNA vaccine candidate for ASF. While Australia has never had an outbreak of ASF, it has recently spread through Asia, with also outbreaks in Indonesia and East Timor (since 2019) and Papua New Guinea (2020).

The scientists will evaluate the vaccine in the secure laboratories at CSIRO’s Australian Centre for Disease Preparedness (ACDP), a high biocontainment facility in Geelong (Victoria state) designed to safely enable research into the world’s most dangerous diseases.

Weakened live vaccines against ASF

Dr David Williams, an ASF expert at ACDP, said, “While first-generation vaccines have recently been approved for use in some parts of Asia, these are weakened live virus vaccines, which have potential to revert back to a disease-causing form and can cause side effects in sows and pigs with infections or other illnesses.”

He continued to say, “CSIRO’s Australian Centre for Disease Preparedness is one of the few labs in the world that can safely work with the virus. We’ll be bringing all our diagnostic tools, reagents and research capability to this challenge, and learning from the experience for future research.”

Eliminating pathogens as they enter a body

MBF Therapeutics CEO, Thomas Tillett, said the DNA vaccine platform is based on technology adapted from immunotherapeutic treatment of human cancer, and aims to eliminate pathogens as they enter the body. “Dr Williams’ and CSIRO’s expertise in the field of ASF, combined with MBF Therapeutics’ innovative T-Max Precision vaccine platform, provides an opportunity to work towards a truly safe and effective ASF vaccine,” Tillett said. “MBF Therapeutics’ ultimate goal is to create a vaccine that can be used safely in all stages of swine production, including sows, while preventing disease in individual animals and limiting transmission within the herd and environment.”